Low density lipoprotein receptor endocytosis in cardiovascular disease and the factors affecting LDL levels

Rupesh Maurya; Gargi Bhattacharjee; Nisarg Gohil; Khushal Khambhati; Shreya Shakhreliya; Aaradhya Bhatnagar; Priyanka Singh; Suresh Ramakrishna; Vijai Singh

doi:10.1016/bs.pmbts.2022.09.010

Low density lipoprotein receptor endocytosis in cardiovascular disease and the factors affecting LDL levels

Prog Mol Biol Transl Sci. 2023:194:333-345. doi: 10.1016/bs.pmbts.2022.09.010. Epub 2022 Oct 29.

Authors

Rupesh Maurya¹, Gargi Bhattacharjee¹, Nisarg Gohil¹, Khushal Khambhati¹, Shreya Shakhreliya², Aaradhya Bhatnagar¹, Priyanka Singh¹, Suresh Ramakrishna³, Vijai Singh⁴

Affiliations

¹ Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, India.
² Department of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.
³ College of Medicine, Hanyang University, Seoul, South Korea; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, South Korea.
⁴ Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, Gujarat, India. Electronic address: vijaisingh15@gmail.com.

PMID: 36631197
DOI: 10.1016/bs.pmbts.2022.09.010

Abstract

Cardiovascular disease (CVD) is the one of major global health issues with approximately 30% of the mortality reported in the mid-income population. Low-density lipoprotein (LDL) plays a crucial role in development of CVD. High LDL along with others forms a plaque and blocks arteries, resulting in CVD. The present chapter deals with the mechanism of receptor-mediated endocytosis of LDL and its management by drugs such as statins and PCSK9 inhibitors along with dietary supplementation for health improvements.

Keywords: Cardiovascular diseases; Cholesterol; Drugs; Endocytosis; Inhibitors; LDL; Receptor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cardiovascular Diseases* / metabolism
Cholesterol, LDL / metabolism
Endocytosis*
Humans
Proprotein Convertase 9
Receptors, LDL* / metabolism

Substances

Cholesterol, LDL
PCSK9 protein, human
Proprotein Convertase 9
Receptors, LDL