Multifunctional sponge scaffold loaded with concentrated growth factors for promoting wound healing

Lianglong Chen; Chaoyang Huang; Yu Zhong; Yujia Chen; Huihui Zhang; Zijun Zheng; Ziwei Jiang; Xuerong Wei; Yujie Peng; Lei Huang; Libin Niu; Yanbin Gao; Jun Ma; Lei Yang

doi:10.1016/j.isci.2022.105835

Multifunctional sponge scaffold loaded with concentrated growth factors for promoting wound healing

iScience. 2022 Dec 20;26(1):105835. doi: 10.1016/j.isci.2022.105835. eCollection 2023 Jan 20.

Authors

Lianglong Chen¹, Chaoyang Huang¹, Yu Zhong¹, Yujia Chen¹, Huihui Zhang¹, Zijun Zheng¹, Ziwei Jiang¹, Xuerong Wei¹, Yujie Peng¹, Lei Huang¹, Libin Niu¹, Yanbin Gao¹, Jun Ma¹, Lei Yang¹

Affiliation

¹ Department of Burns, Nanfang Hospital, Southern Medical University, Jingxi Street, Baiyun District, Guangzhou 510515, P.R. China.

Abstract

Although both are applied in regenerative medicine, acellular dermal matrix (ADM) and concentrated growth factor (CGF) have their respective shortcoming: The functioning of CGF is often hindered by sudden release effects, among other problems, and ADM can only be used in outer dressing for wound healing. In this study, a compound network with physical-chemical double cross-linking was constructed using chemical cross-linking and the intertwining of ADM and chitosan chains under freezing conditions; equipped with good biocompatibility and cell/tissue affinity, the heparin-modified composite scaffold was able to significantly promote cell adhesion and proliferation to achieve adequate fixation and slow down the release of CGF; polydopamine nanoparticles having excellent near-infrared light photothermal conversion ability could significantly promote the survival of rat autologous skin grafts. In a word, this multifunctional composite scaffold is a promising new type of implant biomaterial capable of delivering CGF to promote the healing of full-thickness skin defects.

Keywords: Biological sciences; Biomaterials; Biomedical engineering; Materials science.