Data on common carotid artery occlusion inducing focalized stroke lesions after Pertussis toxin injection

Veronika Leiss; Roland P Piekorz; Salvador Castaneda Vega; Christoph Jacoby; Ulrich Flögel; Katja Pexa; Jürgen Schrader; Bernd J Pichler; Sandra Beer-Hammer; Bernd Nürnberg

doi:10.1016/j.dib.2022.108851

Data on common carotid artery occlusion inducing focalized stroke lesions after Pertussis toxin injection

Data Brief. 2022 Dec 25:46:108851. doi: 10.1016/j.dib.2022.108851. eCollection 2023 Feb.

Authors

Veronika Leiss¹, Roland P Piekorz², Salvador Castaneda Vega^{3

4}, Christoph Jacoby⁵, Ulrich Flögel⁵, Katja Pexa², Jürgen Schrader⁵, Bernd J Pichler^{3

6}, Sandra Beer-Hammer^{1

6}, Bernd Nürnberg¹

Affiliations

¹ Department of Pharmacology, Experimental Therapy and Toxicology, and Interfaculty Center for Pharmacogenomics and Drug Research, Eberhard Karls University Tübingen and University Clinic, Tübingen, Germany.
² Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
³ Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen and University Clinic, Tübingen, Germany.
⁴ Department of Nuclear Medicine and Clinical Molecular Imaging, Eberhard Karls University Tübingen and University Clinic, Tübingen, Germany.
⁵ Institute of Molecular Cardiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
⁶ Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", Eberhard Karls University, Tübingen, Germany.

Abstract

This article contains raw and processed data related to research published by Vega et al. (2022). This complementary dataset provides further insight into the experimental validation of a single common carotid artery occlusion (CCAO) model upon pretreatment with pertussis toxin (PTX). We present data showing the extent of different PTX concentrations on neurological severity measured by Bederson score following CCAO. In addition, data indicate a protective effect of isoflurane on cerebral infarction and neurological deficits, as well as the consequences of PTX pretreatment on reperfusion after occlusion using time-of-flight magnetic resonance angiography. With these data, we aim to provide detailed experimental settings of this newly described model.

Keywords: Angiography; CCAO, Common carotid artery occlusion; Gi proteins; PTX, Pertussis Toxin; ischemic stroke; murine model.