The role of PIWI-interacting RNA in naringin pro-angiogenesis by targeting HUVECs

Yixing Pi; Zitian Liang; Qianzhou Jiang; Ding Chen; Zhikang Su; Yuanting Ouyang; Zhiyi Zhang; Jiaohong Liu; Siyi Wen; Li Yang; Tao Luo; Lvhua Guo

doi:10.1016/j.cbi.2023.110344

The role of PIWI-interacting RNA in naringin pro-angiogenesis by targeting HUVECs

Chem Biol Interact. 2023 Feb 1:371:110344. doi: 10.1016/j.cbi.2023.110344. Epub 2023 Jan 6.

Authors

Yixing Pi¹, Zitian Liang¹, Qianzhou Jiang¹, Ding Chen¹, Zhikang Su¹, Yuanting Ouyang¹, Zhiyi Zhang¹, Jiaohong Liu¹, Siyi Wen¹, Li Yang², Tao Luo³, Lvhua Guo⁴

Affiliations

¹ Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, PR China.
² Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, PR China. Electronic address: 2019686001@gzhmu.edu.cn.
³ Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, PR China. Electronic address: 2011686028@gzhmu.edu.cn.
⁴ Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, PR China. Electronic address: 2010686002@gzhmu.edu.cn.

PMID: 36623717
DOI: 10.1016/j.cbi.2023.110344

Abstract

Angiogenesis is a biological process in which resting endothelial cells start proliferating, migrating and forming new blood vessels. Angiogenesis is particularly important in the repair of bone tissue defects. Naringin (NG) is the main active monomeric component of traditional Chinese medicine, which has various biological activities, such as anti-osteoporosis, anti-inflammatory, blood activation and microcirculation improvement. At present, the mechanism of naringin in the process of angiogenesis is not clear. PIWI protein-interacting RNA (piRNA) is a small noncoding RNA (sncRNA) that has the functions of regulating protein synthesis, regulating the structure of chromatin and the genome, stabilizing mRNA and others. Several studies have demonstrated that piRNAs can mediate the angiogenesis process. Whether naringin can interfere with the process of angiogenesis by regulating piRNAs and related target genes deserves further exploration. Thus, the purpose of this study was to validate the potential angiogenic and bone regeneration properties and related mechanisms of naringin both in vivo and in vitro.

Keywords: Angiogenesis; Bone defect; Naringin; PIWI-Interacting RNA.

MeSH terms

Endothelial Cells / metabolism
Flavanones* / pharmacology
Piwi-Interacting RNA*
RNA, Small Interfering / metabolism

Substances

RNA, Small Interfering
Piwi-Interacting RNA
naringin
Flavanones