Dye-cored polylysine dendrimer as luminescent nanoplatform for imaging-guided anticancer drug delivery

Pengyu Zhu; Muhammad Rizwan Younis; Guiqi Ma; Qianting Zhang; Ruibing An; Kaiqi Wang; Jian Dong

doi:10.1016/j.colsurfb.2023.113130

Dye-cored polylysine dendrimer as luminescent nanoplatform for imaging-guided anticancer drug delivery

Colloids Surf B Biointerfaces. 2023 Feb:222:113130. doi: 10.1016/j.colsurfb.2023.113130. Epub 2023 Jan 5.

Authors

Pengyu Zhu¹, Muhammad Rizwan Younis², Guiqi Ma¹, Qianting Zhang¹, Ruibing An³, Kaiqi Wang⁴, Jian Dong⁵

Affiliations

¹ Institute of Optical Functional Materials for Biomedical Imaging, School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Science, Taian, Shandong 271016, PR China.
² Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, PR China; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic Engineering Shenzhen University, Shenzhen 518060, PR China.
³ Institute of Optical Functional Materials for Biomedical Imaging, School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Science, Taian, Shandong 271016, PR China. Electronic address: anruibing@sdfmu.edu.cn.
⁴ Institute of Optical Functional Materials for Biomedical Imaging, School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Science, Taian, Shandong 271016, PR China. Electronic address: wangkaiqi@sdfmu.edu.cn.
⁵ Institute of Optical Functional Materials for Biomedical Imaging, School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Science, Taian, Shandong 271016, PR China. Electronic address: dongjian@sdfmu.edu.cn.

PMID: 36623376
DOI: 10.1016/j.colsurfb.2023.113130

Abstract

Dendrimers have numerous applications in imaging and drug delivery. Designing a dendrimer diagnostic platform with a well-defined structure and controlled drug delivery is a formidable challenge. Here, we design dendritic polymer-platinum conjugates (G5-PEG-Pt) as pH-responsive nanovesicles for imaging-guided platinum drug delivery. The G5-PEG-Pt have a well-defined structure, intrinsically bright fluorescence, and acid-responsive drug release. The pH-responsive G5-PEG-Pt could rapidly release the platinum drug at acidic pH (5.0) than neutral pH (7.4). The G5-PEG-Pt could enter SKOV-3 human ovarian cancer cells by the endocytosis pathway and exhibited comparative cytotoxicity to free cisplatin. By virtue of the prolonged blood circulation time and the enhanced permeability and retention (EPR) effect, a 4.4-fold higher tumor platinum uptake than that of free cisplatin was achieved, potentially enhancing the therapeutic indexes of the platinum drug. Therefore, these pH-responsive platinum and fluorescent dendrimer conjugates are expected to be potent in vivo cancer optical imaging and therapy platforms.

Keywords: Dendrimer; Nanomedicine; Platinum; pH-responsive.

MeSH terms

Antineoplastic Agents* / chemistry
Cell Line, Tumor
Cisplatin / pharmacology
Dendrimers* / chemistry
Doxorubicin / chemistry
Doxorubicin / pharmacology
Female
Humans
Ovarian Neoplasms* / diagnostic imaging
Ovarian Neoplasms* / drug therapy
Platinum
Polylysine

Substances

Dendrimers
Cisplatin
Polylysine
Doxorubicin
Platinum
Antineoplastic Agents