This Healthcare Cost and Utilization Project (HCUP) Statistical Brief presents statistics on SUD-related ED visits by patient race and ethnicity using weighted estimates from the 2019 Nationwide Emergency Department Sample (NEDS). SUDs include disorders involving alcohol, cannabis, stimulants, opioids, sedatives, hallucinogens, and inhalants, as well as other substances. The number and percentage of SUD-related ED visits are presented for select patient characteristics and primary expected payer. The population rate of SUD-related ED visits is presented by race and ethnicity for select demographic characteristics, including sex, age group, rural/urban location, and the social vulnerability of the county in which the individual resides (i.e., community’s ability to prevent human suffering and financial loss during a disaster). Because of the large sample size of the NEDS data, small differences can be statistically significant. Thus, only differences greater than or equal to 10 percent are discussed in the text.