Two new benzophenones from the moss Pogonatum spinulosum

Wen-Bin Duan; An-Tang Peng; Shi-Nong Yuan; Shao-Nan Wang; Bo-Wen Li; Xu-Hong Duan

doi:10.1080/14786419.2023.2164857

Two new benzophenones from the moss Pogonatum spinulosum

Nat Prod Res. 2023 Jan 9:1-6. doi: 10.1080/14786419.2023.2164857. Online ahead of print.

Authors

Wen-Bin Duan^{1

2}, An-Tang Peng³, Shi-Nong Yuan^{4

5}, Shao-Nan Wang^{4

5}, Bo-Wen Li⁴, Xu-Hong Duan^{4

5}

Affiliations

¹ Department of Hepatobiliary Surgery, the First Affiliated Hospital of Hunan Normal University, Changsha, China.
² Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital (the First Affiliated Hospital of Hunan Normal University), Changsha, China.
³ Drug Manufacturing Room, The Traditional Chinese Medicine Hospital of Shijiazhuang, Shijiazhuang, China.
⁴ College of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China.
⁵ Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, Shijiazhuang, China.

PMID: 36622886
DOI: 10.1080/14786419.2023.2164857

Abstract

Two new benzophenone derivatives (1 and 2), named Pogonatone C and pogonatone D, were isolated from the moss Pogonatum spinulosum. Their structures were elucidated by spectroscopic data analyses. The cytotoxicity of compounds for HepG2, HCT-116, A-549 and PANC-1 cells line was also evaluated by using the MTT method. Pogonatone C (1) displays high cytotoxicity on PANC-1 cell with IC₅₀ value of 9.2 μM.

Keywords: Pogonatum spinulosum; Polytrichaceae; benzophenones; cytotoxicity.