Protein SUMOylation and phase separation: partners in stress?

Abstract

Protein SUMOylation is one of the most prevalent post-translational modifications (PTMs) and important for maintaining cellular homeostasis in response to various cellular stresses. Emerging evidence reveals the role of liquid-liquid phase separation (LLPS)/biomolecular condensates in cellular SUMOylation, potentially solving a puzzle regarding the cellular mechanism of SUMOylation regulation.

Keywords: SUMOylation; biomolecular condensate; liquid–liquid phase separation; multivalent interaction; stress response.