Covalent Rescue of Mutant p53

Cancer Discov. 2023 Jan 9;13(1):14-16. doi: 10.1158/2159-8290.CD-22-1212.

Abstract

p53 mutant proteins are widely expressed in human cancer. In this issue, Guiley and Shokat describe the development of compounds that rescue the function of the Y220C mutant p53 protein by forming covalent complexes with the target protein. See related article by Guiley and Shokat, p. 56 (3).

Publication types

  • Editorial
  • Comment

MeSH terms

  • Humans
  • Neoplasms* / drug therapy
  • Neoplasms* / genetics
  • Tumor Suppressor Protein p53* / genetics
  • Tumor Suppressor Protein p53* / metabolism

Substances

  • Tumor Suppressor Protein p53