Recent developments in multifunctional neural probes for simultaneous neural recording and modulation

Hongbian Li; Jinfen Wang; Ying Fang

doi:10.1038/s41378-022-00444-5

Recent developments in multifunctional neural probes for simultaneous neural recording and modulation

Microsyst Nanoeng. 2023 Jan 4:9:4. doi: 10.1038/s41378-022-00444-5. eCollection 2023.

Authors

Hongbian Li¹, Jinfen Wang¹, Ying Fang^{1

2}

Affiliations

¹ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China.
² CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, 200031 China.

Abstract

Neural probes are among the most widely applied tools for studying neural circuit functions and treating neurological disorders. Given the complexity of the nervous system, it is highly desirable to monitor and modulate neural activities simultaneously at the cellular scale. In this review, we provide an overview of recent developments in multifunctional neural probes that allow simultaneous neural activity recording and modulation through different modalities, including chemical, electrical, and optical stimulation. We will focus on the material and structural design of multifunctional neural probes and their interfaces with neural tissues. Finally, future challenges and prospects of multifunctional neural probes will be discussed.

Keywords: Biosensors.

Publication types

Review