Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio

Zengzeng Lu; Yuqian Fu; Xueyuan Zhou; Hekang Du; Qi Chen

doi:10.3389/fmicb.2022.1065945

Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio

Front Microbiol. 2022 Dec 22:13:1065945. doi: 10.3389/fmicb.2022.1065945. eCollection 2022.

Authors

Zengzeng Lu¹, Yuqian Fu¹, Xueyuan Zhou¹, Hekang Du¹, Qi Chen¹

Affiliation

¹ Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, Fujian Normal University Qishan Campus, Fuzhou, China.

Abstract

The cyclic GMP-AMP (cGAMP) synthase (cGAS) recognizes cytosolic DNA and synthesizes the second messenger, cGAMP, thus activating the adaptor protein stimulator of interferon genes (STING) and initiating the innate immune responses against microbial infections. cGAS-STING pathway has been crucially implicated in autoimmune diseases, cellular senescence, and cancer immunotherapy, while the cGAS-like receptors in bacteria can protect it against viral infections. Dinucleotide cyclase in Vibrio (DncV) is a dinucleotide cyclase originally identified in Vibrio cholerae. The synthesis of cyclic nucleotides by DncV, including c-di-GMP, c-di-AMP, and cGAMP mediates bacterial colonization, cell membrane formation, and virulence. DncV is a structural and functional homolog of the mammalian cytoplasmic DNA sensor, cGAS, implicating cGAS-STING signaling cascades may have originated in the bacterial immune system. Herein, we summarize the roles of DncV in bacterial immunity, which are expected to provide insights into the evolution of cGAS-STING signaling.

Keywords: CDNs; DncV; OAS; bacterial immunity; cGAS.

Publication types

Review