Abnormal prolactin response to haloperidol challenge in men with schizophrenia

Am J Psychiatry. 1987 Oct;144(10):1335-7. doi: 10.1176/ajp.144.10.1335.

Abstract

Fourteen drug-free male patients with schizophrenia had a smaller and slower prolactin response to 0.5 mg of intravenous haloperidol than 14 normal age- and sex-matched control subjects. This finding supports the presence of dopaminergic dysfunction in schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Dopamine / physiology
  • Haloperidol / pharmacology*
  • Humans
  • Male
  • Prolactin / blood*
  • Schizophrenia / blood*
  • Schizophrenia / diagnosis
  • Schizophrenia / physiopathology

Substances

  • Prolactin
  • Haloperidol
  • Dopamine