Optical coherence tomography angiography with adaptive multi-time interval

Bin He; Yuxin Zhang; Zhe Meng; Zhijun He; Chengming Wang; Zhenyu Chen; Zichen Yin; Zhangwei Hu; Yejiong Shi; Ning Zhang; Wenxin Zhang; Guihuai Wang; Ping Xue

doi:10.1002/jbio.202200340

Optical coherence tomography angiography with adaptive multi-time interval

J Biophotonics. 2023 May;16(5):e202200340. doi: 10.1002/jbio.202200340. Epub 2023 Jan 14.

Authors

Bin He¹, Yuxin Zhang², Zhe Meng³, Zhijun He³, Chengming Wang⁴, Zhenyu Chen¹, Zichen Yin¹, Zhangwei Hu¹, Yejiong Shi¹, Ning Zhang⁵, Wenxin Zhang⁶, Guihuai Wang³, Ping Xue¹

Affiliations

¹ State Key Laboratory of Low-dimensional Quantum Physics and Department of Physics, Tsinghua University and Beijing Advanced Innovation Center for Structural Biology, Beijing, China.
² Department of Materials, Imperial College London, London, UK.
³ Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine and Institute of Precision Medicine, Tsinghua University, Beijing, China.
⁴ Jinsp Company Limited, Beijing, China.
⁵ Institute of Forensic Science, Ministry of Public Security, Beijing, China.
⁶ College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications, Nanjing, China.

PMID: 36617672
DOI: 10.1002/jbio.202200340

Abstract

Optical coherence tomography angiography (OCTA) can provide in vivo three-dimensional microvasculature information of bio-tissues, but it is sensitive to motion and time-consuming. To overcome these limitations, we propose an adaptive multiple time interval correlation mapping OCTA with a time-efficient scanning protocol and motion compensation algorithms. A spectral-domain OCT with a center wavelength of 850 nm, A-scan rate of 120 kHz and spatial resolution of 4.1 μm (axial) × 6.9 μm (lateral) is built to reconstruct the microvascular networks in the human arm. By adaptive optimization of the weights of different time interval B-scan angiograms, our novel OCTA technique achieves better performance with a visible vascular density increase of ~67% and a signal-to-noise ratio enhancement of ~11.6%.

Keywords: adaptive scanning; imaging processing; optical coherence tomography angiography.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Angiography* / methods
Humans
Motion
Signal-To-Noise Ratio
Tomography, Optical Coherence* / methods