Chiral Silanols: Strategies and Tactics for Their Synthesis

Abstract

Silanols are valuable and important compounds, which have found widespread applications in the field of materials science, synthetic chemistry, and medicinal chemistry. Although a handful of approaches have been developed for the synthesis of various silanols, access to enantioenriched silicon-stereogenic silanols remains underdeveloped. This Concept article intends to summarize and highlight recent advances in the construction of silicon-stereogenic silanols and endeavors to encourage further research in this area.

Keywords: chiral silanols; enantioselective synthesis; resolution of racemates; silicon-stereogenic silanes; stereospecific transformation.