Research Progress of H2S Donors Conjugate Drugs Based on ADTOH

Shuai Wen; Changchang Cao; Jianwen Ge; Wenzhe Yang; Yan Wang; Yi Mou

doi:10.3390/molecules28010331

Research Progress of H₂S Donors Conjugate Drugs Based on ADTOH

Molecules. 2022 Dec 31;28(1):331. doi: 10.3390/molecules28010331.

Authors

Shuai Wen¹, Changchang Cao¹, Jianwen Ge¹, Wenzhe Yang¹, Yan Wang¹, Yi Mou¹

Affiliation

¹ College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou 225300, China.

Abstract

H₂S is an endogenous gas signaling molecule and its multiple biological effects have been demonstrated. The abnormal level of H₂S is closely related to the occurrence and development of many diseases, and H₂S donors has important pharmacological implications. In recent years, H₂S donors represented by ADTOH (5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione) are often used to synthesize new 'conjugate' compounds that can release H₂S and parent drugs. These hybrids retain the pharmacological activity of the parent drugs and H₂S and have a synergistic effect. ADTOH and parent drug hybrids have become one of the important strategies for the development of H₂S donor conjugate drugs. This review summarizes molecular hybrids between ADTOH and clinical drugs to provide new ideas for the study of H₂S donor drug design.

Keywords: ADTOH; H2S donors; clinical drugs; conjugate drugs.

Publication types

Review

MeSH terms

Drug Design
Hydrogen Sulfide* / pharmacology
Signal Transduction
Thiones

Substances

Hydrogen Sulfide
Thiones

Grants and funding

This study was supported by Projects 81703363 of the National Natural Science Foundation of China; Six Talent Peaks Project in Jiangsu Province (YY-110); the Natural Science Fund for colleges and universities in Jiangsu Province (21KJB350008); 333 High Level Talent Training Project; Science and Technology Support Program (Social Development) of Taizhou (TN202135).