Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation

Vladimir Khavinson; Natalia Linkova; Anastasiia Dyatlova; Raisa Kantemirova; Kirill Kozlov

doi:10.3390/cells12010106

Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation

Cells. 2022 Dec 27;12(1):106. doi: 10.3390/cells12010106.

Authors

Vladimir Khavinson^{1

2}, Natalia Linkova^{1

3}, Anastasiia Dyatlova¹, Raisa Kantemirova^{4

5}, Kirill Kozlov^{1

6}

Affiliations

¹ Department of Biogerontology, Saint Petersburg Institute of Bioregulation and Gerontology, 197110 Saint Petersburg, Russia.
² Group of Peptide Regulation of Aging, Pavlov Institute of Physiology of Russian Academy of Sciences, 199034 Saint Petersburg, Russia.
³ The Department of Therapy, Geriatrics and Anti-Age Medicine, Academy of Postgraduate Education under of FSBU FSCC of FMBA of Russia, 125371 Moscow, Russia.
⁴ Department of Therapy, Federal Scientific Center of Rehabilitation of the Disabled Named after G.A. Albrecht Ministry of Labor and Social Protection, 195067 Saint Petersburg, Russia.
⁵ Department of Hospital Therapy, Saint Petersburg State University, 199034 Saint Petersburg, Russia.
⁶ First Department and Clinic of Surgery, S. M. Kirov Military Medical Academy, 194044 Saint Petersburg, Russia.

Abstract

A senescence-associated secretory phenotype (SASP) and a mild inflammatory response characteristic of senescent cells (inflammaging) form the conditions for the development of cardiovascular diseases: atherosclerosis, coronary heart disease, and myocardial infarction. The purpose of the review is to analyze the pool of signaling molecules that form SASP and inflammaging in cells of the cardiovascular system and to search for targets for the action of vasoprotective peptides. The SASP of cells of the cardiovascular system is characterized by a change in the synthesis of anti-proliferative proteins (p16, p19, p21, p38, p53), cytokines characteristic of inflammaging (IL-1α,β, IL-4, IL-6, IL-8, IL-18, TNFα, TGFβ1, NF-κB, MCP), matrix metalloproteinases, adhesion molecules, and sirtuins. It has been established that peptides are physiological regulators of body functions. Vasoprotective polypeptides (liraglutide, atrial natriuretic peptide, mimetics of relaxin, Ucn1, and adropin), KED tripeptide, and AEDR tetrapeptide regulate the synthesis of molecules involved in inflammaging and SASP-forming cells of the cardiovascular system. This indicates the prospects for the development of drugs based on peptides for the treatment of age-associated cardiovascular pathology.

Keywords: SASP; aging; cardiovascular pathology; inflammaging; peptides.

Publication types

Review

MeSH terms

Cardiovascular System* / metabolism
Cellular Senescence* / physiology
Cytokines / metabolism
NF-kappa B / metabolism
Senescence-Associated Secretory Phenotype

Substances

Cytokines
NF-kappa B

Grants and funding

This research received no external funding.