Essential Role of Multi-Omics Approaches in the Study of Retinal Vascular Diseases

Yi Lei; Ju Guo; Shikun He; Hua Yan

doi:10.3390/cells12010103

Essential Role of Multi-Omics Approaches in the Study of Retinal Vascular Diseases

Cells. 2022 Dec 26;12(1):103. doi: 10.3390/cells12010103.

Authors

Yi Lei^{1

2

3}, Ju Guo^{1

2

3}, Shikun He⁴, Hua Yan^{1

2

3}

Affiliations

¹ Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin 300052, China.
² Laboratory of Molecular Ophthalmology, Tianjin Medical University, Tianjin 300070, China.
³ Tianjin Key Laboratory of Ocular Trauma, Tianjin Medical University, Tianjin 300070, China.
⁴ Department of Pathology and Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

Abstract

Retinal vascular disease is a highly prevalent vision-threatening ocular disease in the global population; however, its exact mechanism remains unclear. The expansion of omics technologies has revolutionized a new medical research methodology that combines multiple omics data derived from the same patients to generate multi-dimensional and multi-evidence-supported holistic inferences, providing unprecedented opportunities to elucidate the information flow of complex multi-factorial diseases. In this review, we summarize the applications of multi-omics technology to further elucidate the pathogenesis and complex molecular mechanisms underlying retinal vascular diseases. Moreover, we proposed multi-omics-based biomarker and therapeutic strategy discovery methodologies to optimize clinical and basic medicinal research approaches to retinal vascular diseases. Finally, the opportunities, current challenges, and future prospects of multi-omics analyses in retinal vascular disease studies are discussed in detail.

Keywords: biomarker; methodologies; multi-omics; retinal vascular diseases; therapeutic strategies.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Genomics* / methods
Humans
Metabolomics / methods
Multiomics
Proteomics / methods
Vascular Diseases* / genetics

Grants and funding

This work was funded by the National Natural Science Foundation of China, grant numbers 2021YFC2401404 and the Science and Technology Plan Projects of Tianjin [grant number 20JCZXJC00180].