Orthopedic infections due to Trichosporon species: Case series and literature review

Med Mycol. 2022 Dec 29;61(1):myad001. doi: 10.1093/mmy/myad001.

Abstract

Reports of orthopedic fungal infections caused by Trichosporon species are extremely scarce, thus we aimed to describe a case series and review the cases published in the literature. Patients were retrospectively included if a previous culture of bone, joint, or soft tissues had resulted positive for Trichosporon species along with a clinical diagnosis of an orthopedic infection. Eight patients were included with diverse orthopedic conditions, most of them cases of osteomyelitis. The main isolated species was Trichosporon asahii. All patients were treated with antifungals, mainly voriconazole, and surgical management, resulting in high rates of clinical improvement and low associated mortality.

Keywords: Trichosporon; fungal infection; orthopedic infection; osteomyelitis; prosthetic infection.

Plain language summary

Reports of orthopedic infections caused by Trichosporon species are scarce. We described a case series of orthopedic infections caused by Trichosporon species and reviewed the previous published cases in the literature. We observed a high rate of clinical improvement and a low associated mortality.

Publication types

  • Review

MeSH terms

  • Animals
  • Antifungal Agents / therapeutic use
  • Retrospective Studies
  • Trichosporon*
  • Trichosporonosis* / diagnosis
  • Trichosporonosis* / drug therapy
  • Trichosporonosis* / veterinary
  • Voriconazole / therapeutic use

Substances

  • Antifungal Agents
  • Voriconazole