Cochlear transduction via cerebrospinal fluid delivery of AAV in non-human primates

Paul T Ranum; Luis Tecedor; Megan S Keiser; Yong Hong Chen; David E Leib; Xueyuan Liu; Beverly L Davidson

doi:10.1016/j.ymthe.2022.12.018

Cochlear transduction via cerebrospinal fluid delivery of AAV in non-human primates

Mol Ther. 2023 Mar 1;31(3):609-612. doi: 10.1016/j.ymthe.2022.12.018. Epub 2023 Jan 6.

Authors

Paul T Ranum¹, Luis Tecedor², Megan S Keiser², Yong Hong Chen², David E Leib², Xueyuan Liu², Beverly L Davidson³

Affiliations

¹ Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Postdoctoral Training Program in Genomic Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
³ Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

No abstract available

Keywords: AAV; African green; CSF; adeno-associated virus; auditory hair cells; bene therapy; cerebrosipinal fluid; cochlea; gearing loss; inner hair cells; macaque; non-human primate.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cochlea*
Dependovirus / genetics
Gene Transfer Techniques*
Genetic Vectors / genetics
Primates

Grants and funding

T32 HG009495/HG/NHGRI NIH HHS/United States