Comparison of glycerophospholipid and sphingolipid in mature milk from different sampled regions in the Chinese human milk project (CHMP) study

Huiquan Zhu; Xiaodan Wang; Wenyuan Zhang; Jianchun Pan; Yumen Zhang; Yunna Wang; Chuqi Jiang; Qiaosi Wei; Xin Si; Shilong Jiang; Jing Lu; Jiaping Lv

doi:10.1016/j.foodchem.2022.135311

Comparison of glycerophospholipid and sphingolipid in mature milk from different sampled regions in the Chinese human milk project (CHMP) study

Food Chem. 2023 Jun 1:410:135311. doi: 10.1016/j.foodchem.2022.135311. Epub 2022 Dec 24.

Authors

Huiquan Zhu¹, Xiaodan Wang², Wenyuan Zhang³, Jianchun Pan⁴, Yumen Zhang¹, Yunna Wang¹, Chuqi Jiang⁴, Qiaosi Wei⁴, Xin Si¹, Shilong Jiang⁵, Jing Lu⁶, Jiaping Lv⁷

Affiliations

¹ Institute of Food Science and Technology, Chinese Academy of Agricultural Science, Beijing, China.
² Institute of Food Science and Technology, Chinese Academy of Agricultural Science, Beijing, China; Adaptation Physiology Group, Wageningen University & Research, Wageningen, the Netherlands.
³ Institute of Food Science and Technology, Chinese Academy of Agricultural Science, Beijing, China; Laboratory of Biochemistry, Wageningen University & Research, Wageningen, the Netherlands.
⁴ PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development, Beijing, China; Nutrition and Metabolism Research Division, Innovation Center, Heilongjiang Feihe Dairy Co., Ltd., Beijing, China.
⁵ PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development, Beijing, China; Nutrition and Metabolism Research Division, Innovation Center, Heilongjiang Feihe Dairy Co., Ltd., Beijing, China. Electronic address: jiangshilong@feihe.com.
⁶ School of Food and Health, Beijing Technology and Business University, Beijing, China. Electronic address: lujing@btbu.edu.cn.
⁷ Institute of Food Science and Technology, Chinese Academy of Agricultural Science, Beijing, China. Electronic address: lvjiapingcaas@126.com.

PMID: 36610088
DOI: 10.1016/j.foodchem.2022.135311

Abstract

Milk phospholipids (PLs) are critical components of infant growth. This study aimed to discover PL in mature human milk (HM) from China (n = 201) and mainly assessed the effect caused by sampled regions. The average total PL concentration was quantified from 3.65 to 11.25 mg per g of lipid, and the major PL class identified was sphingomyelin (SM, 38.06-47.62 %), followed by phosphatidylcholine (PC, 29.61-34.39 %), and phosphatidylethanolamine (PE, 10.54-24.46 %). In addition, the 36:2 (18:0/18:2), 38:6 (16:0/22:6), 40:1 (d18:1/22:0), and 42:2 (d18:1/24:1) were the most abundant molecular species identified in glycerophospholipid and SM molecular species respectively. Some PL molecular species were strongly related with region of sampling, like lysophosphatidylinositol 18:1 was only detected in Beijing. In conclusion, those findings showed that the PL molecular species and concentration of HM had significant regional diversity, and it will give the Chinese human milk database more accurate PL data.

Keywords: Chinese human milk; Mature milk; Molecular species; Phospholipid; Sampled regions.

MeSH terms

East Asian People
Glycerophospholipids*
Humans
Infant
Milk, Human*
Phospholipids
Sphingolipids

Substances

Glycerophospholipids
Sphingolipids
Phospholipids