Pediatric high-grade glioma MYCN is frequently associated with Li-Fraumeni syndrome

Léa Guerrini-Rousseau; Arnault Tauziède-Espariat; David Castel; Etienne Rouleau; Philipp Sievers; Raphaël Saffroy; Kévin Beccaria; Thomas Blauwblomme; Lauren Hasty; Franck Bourdeaut; Jacques Grill; Pascale Varlet; Marie-Anne Debily

doi:10.1186/s40478-022-01490-w

Pediatric high-grade glioma MYCN is frequently associated with Li-Fraumeni syndrome

Acta Neuropathol Commun. 2023 Jan 6;11(1):3. doi: 10.1186/s40478-022-01490-w.

Authors

Léa Guerrini-Rousseau^#^{1

2}, Arnault Tauziède-Espariat^#^{3

4}, David Castel², Etienne Rouleau⁵, Philipp Sievers^{6

7}, Raphaël Saffroy⁸, Kévin Beccaria⁹, Thomas Blauwblomme⁹, Lauren Hasty¹⁰, Franck Bourdeaut¹¹, Jacques Grill^{1

2}, Pascale Varlet^{10

12}, Marie-Anne Debily^{2

13}

Affiliations

¹ Department of Child and Adolescents Oncology, Gustave Roussy, Université Paris-Saclay, 94805, Villejuif, France.
² Molecular Predictors and New Targets in Oncology, INSERM U981, Gustave Roussy, Université Paris-Saclay, 94805, Villejuif, France.
³ Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, 1, rue Cabanis, 75014, Paris, France. a.tauziede-espariat@ghu-paris.fr.
⁴ Inserm, UMR 1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France. a.tauziede-espariat@ghu-paris.fr.
⁵ Department of Biology and Pathology, Tumor Genetics Service, Gustave Roussy, Université Paris-Saclay, 94805, Villejuif, France.
⁶ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
⁷ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁸ Department of Biochemistry and Oncogenetic, Paul Brousse Hospital, 94804, Villejuif, France.
⁹ Department of Pediatric Neurosurgery, Necker Hospital, APHP, Université Paris Cité, 75015, Paris, France.
¹⁰ Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, 1, rue Cabanis, 75014, Paris, France.
¹¹ INSERM U830, Laboratory of Translational Research in Pediatric Oncology, SIREDO Pediatric Oncology Center, Curie Institute, Paris, France.
¹² Inserm, UMR 1266, IMA-Brain, Institut de Psychiatrie et Neurosciences de Paris, Paris, France.
¹³ Univ. Evry, Université Paris-Saclay, 91000, Evry, France.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Child
Genetic Predisposition to Disease
Germ-Line Mutation
Glioma* / complications
Glioma* / genetics
Humans
Li-Fraumeni Syndrome* / complications
Li-Fraumeni Syndrome* / genetics
N-Myc Proto-Oncogene Protein / genetics
Tumor Suppressor Protein p53 / genetics

Substances

N-Myc Proto-Oncogene Protein
Tumor Suppressor Protein p53
MYCN protein, human