Strength in diversity: Intra-cellular metabolite sharing enhances longevity

Cell. 2023 Jan 5;186(1):8-9. doi: 10.1016/j.cell.2022.12.012.

Abstract

Much of our foundational knowledge of cellular biology comes from studies in budding yeast, often described as a simple unicellular eukaryotic model. In this issue of Cell, Correia-Melo et al. describe an unappreciated feature of yeast biology involving intra-cellular metabolite exchange, where cells adapt and respond as part of a community, and go on to show that sharing of resources linked to methionine metabolism enhances longevity of cooperating cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Cytoplasm
  • Eukaryotic Cells
  • Longevity*
  • Saccharomyces cerevisiae / metabolism
  • Saccharomycetales*