Invasion of the germinal centers

Daniel P Maurer; Aaron G Schmidt

doi:10.1016/j.cell.2022.12.023

Invasion of the germinal centers

Cell. 2023 Jan 5;186(1):12-14. doi: 10.1016/j.cell.2022.12.023.

Authors

Daniel P Maurer¹, Aaron G Schmidt²

Affiliations

¹ Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. Electronic address: dmaurer@g.harvard.edu.
² Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: aschmidt@crystal.harvard.edu.

PMID: 36608649
DOI: 10.1016/j.cell.2022.12.023

Abstract

After vaccination or infection, long-lived germinal centers can produce antibodies with high affinity and specificity against pathogens. In this issue of Cell, de Carvalho et al. and Hägglöf et al. show that naive B cells can invade germinal centers, replacing B cells that entered early and changing features of antibody production. These findings have implications for vaccine design.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Antibody Formation
B-Lymphocytes*
Germinal Center*
Vaccination