Tanshinone I: Pharmacological activities, molecular mechanisms against diseases and future perspectives

Liyuan Ke; Chenhui Zhong; Zhijie Chen; Ziyao Zheng; Shaoguang Li; Bing Chen; Qiaoyi Wu; Hong Yao

doi:10.1016/j.phymed.2022.154632

Tanshinone I: Pharmacological activities, molecular mechanisms against diseases and future perspectives

Phytomedicine. 2023 Feb:110:154632. doi: 10.1016/j.phymed.2022.154632. Epub 2022 Dec 27.

Authors

Liyuan Ke¹, Chenhui Zhong¹, Zhijie Chen¹, Ziyao Zheng¹, Shaoguang Li¹, Bing Chen², Qiaoyi Wu³, Hong Yao⁴

Affiliations

¹ Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, 350122, China.
² Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, 350122, China; Key Laboratory of Nanomedical Technology (Education Department of Fujian Province), School of Pharmacy, Fujian Medical University, Fuzhou, China.
³ Department of Trauma and Emergency Surgery, The First Affiliated Hospital of Fujian Medical University, Chazhong Road, Fuzhou, 350004, China. Electronic address: qywu@mail.fjmu.edu.cn.
⁴ Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, 350122, China; Key Laboratory of Nanomedical Technology (Education Department of Fujian Province), School of Pharmacy, Fujian Medical University, Fuzhou, China; Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, Fuzhou, 350122, China. Electronic address: hongyao@mail.fjmu.edu.cn.

PMID: 36608501
DOI: 10.1016/j.phymed.2022.154632

Abstract

Background: Tanshinone I (Tan I) is known as one of the important active components in Salvia miltiorrhiza. In recent years, Tan I has received a substantial amount of attention from the research community for various studies being updated and has been shown to possess favorable activities including anti-oxidative stress, regulation of cell autophagy or apoptosis, inhibition of inflammation, etc. PURPOSE: To summarize the investigation progress on the anti-disease efficacy and effect mechanism of Tan I in recent years, and provide perspectives for future study on the active ingredient.

Method: Web of Science and PubMed databases were used to search for articles related to "Tanshinone I" published from 2010 to 2022. Proteins or genes and signaling pathways referring to Tan I against diseases were summarized and classified along with its different therapeutic actions. Protein-protein interaction (PPI) analysis was then performed, followed by molecular docking between proteins with high node degree and Tan I, as well as bioinformactic analysis including GO, KEGG and DO enrichment analysis with the collected proteins or genes.

Results: Tan I shows multiple therapeutic effects, including protection of the cardiovascular system, anti-cancer, anti-inflammatory, anti-neurodegenerative diseases, etc. The targets (proteins or genes) affected by Tan I against diseases involve Bcl-2, Bid, ITGA2, PPAT, AURKA, VEGF, PI3K, AKT, PRK, JNK, MMP9, ABCG2, CASP3, Cleaved-caspase-3, AMPKα, PARP, etc., and the regulatory pathways refer to Akt/Nrf2, SAPK/JNK, PI3K/Akt/mTOR, JAK/STAT3, ATF-2/ERK, etc. What's more, AKT1, CASP3, and STAT3 were predicted as the key action targets for Tan I by PPI analysis combined with molecular docking, and the potential therapeutic effects mechanisms against diseases were also further predicted by bioinformatics analyses based on the reported targets, providing new insights into the future investigation and helping to facilitate the drug development of Tan I.

Keywords: Effect mechanism; Perspectives; Pharmacokinetics; Pharmacological effect; Tanshinone I.

Publication types

Review

MeSH terms

Caspase 3 / metabolism
Molecular Docking Simulation
Phosphatidylinositol 3-Kinases* / metabolism
Proto-Oncogene Proteins c-akt* / metabolism

Substances

tanshinone
Proto-Oncogene Proteins c-akt
Caspase 3
Phosphatidylinositol 3-Kinases