Viral subversion of the cell polarity regulator Scribble

Airah Javorsky; Patrick O Humbert; Marc Kvansakul

doi:10.1042/BST20221067

Viral subversion of the cell polarity regulator Scribble

Biochem Soc Trans. 2023 Feb 27;51(1):415-426. doi: 10.1042/BST20221067.

Authors

Airah Javorsky¹, Patrick O Humbert^{1

2

3

4}, Marc Kvansakul^{1

2}

Affiliations

¹ Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.
² Research Centre for Molecular Cancer Prevention, La Trobe University, Melbourne, Victoria 3086, Australia.
³ Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria 3010, Australia.
⁴ Department of Clinical Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia.

Abstract

Scribble is a scaffolding protein that regulates key events such as cell polarity, tumorigenesis and neuronal signalling. Scribble belongs to the LAP family which comprise of 16 Leucine Rich Repeats (LRR) at the N-terminus, two LAP Specific Domains (LAPSD) and four PSD-95/Discs-large/ZO-1 (PDZ) domains at the C-terminus. The four PDZ domains have been shown to be key for a range of protein-protein interactions and have been identified to be crucial mediators for the vast majority of Scribble interactions, particularly via PDZ Binding Motifs (PBMs) often found at the C-terminus of interacting proteins. Dysregulation of Scribble is associated with poor prognosis in viral infections due to subversion of multiple cell signalling pathways by viral effector proteins. Here, we review the molecular details of the interplay between Scribble and viral effector proteins that provide insight into the potential modes of regulation of Scribble mediated polarity signalling.

Keywords: PDZ domain; Scribble; cell polarity; virology.

Publication types

Review

MeSH terms

Cell Polarity* / physiology
Cell Transformation, Neoplastic*
Humans
Protein Binding