Transcriptional programming of pathogenic genes in polycystic kidney disease

Je Yeong Ko; Jong Hoon Park

doi:10.1016/j.kint.2022.10.022

Transcriptional programming of pathogenic genes in polycystic kidney disease

Kidney Int. 2023 Jan;103(1):25-28. doi: 10.1016/j.kint.2022.10.022.

Authors

Je Yeong Ko¹, Jong Hoon Park²

Affiliations

¹ Department of Biological Science, Sookmyung Women's University, Seoul, Korea.
² Department of Biological Science, Sookmyung Women's University, Seoul, Korea. Electronic address: parkjh@sookmyung.ac.kr.

PMID: 36603979
DOI: 10.1016/j.kint.2022.10.022

Abstract

Transcriptional dysregulation is a prominent contributor to the pathogenesis of autosomal dominant polycystic kidney disease. Lakhia et al. identified an enhancer landscape associated with disease genes and its pathologic role in autosomal dominant polycystic kidney disease to understand cyst formation. This commentary discusses these findings reported by Lakhia et al. in the broader contexts of transcriptional programming and the identification of potential autosomal dominant polycystic kidney disease therapeutic targets.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Kidney
Polycystic Kidney, Autosomal Dominant* / therapy