Sticking to your side: A niche for the development of ipsilateral retinal projections

Madison T Gray; Julie L Lefebvre

doi:10.1016/j.neuron.2022.12.017

Sticking to your side: A niche for the development of ipsilateral retinal projections

Neuron. 2023 Jan 4;111(1):5-8. doi: 10.1016/j.neuron.2022.12.017.

Authors

Madison T Gray¹, Julie L Lefebvre²

Affiliations

¹ Program for Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada.
² Program for Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Canada. Electronic address: julie.lefebvre@sickkids.ca.

PMID: 36603550
DOI: 10.1016/j.neuron.2022.12.017

Abstract

Visual impairments in albinism result from decreased ipsilateral retinal projections. In this issue of Neuron, Slavi, Balasubramanian, and colleagues¹ demonstrate how low CyclinD2 in the ciliary marginal zone perturbs generation of ipsilaterally projecting RGCs and that restoring CyclinD2 improves vision in albino mice.

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MeSH terms

Albinism*
Animals
Mice
Retina
Retinal Ganglion Cells*
Vision, Ocular
Visual Pathways