Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers

Xiaoran Duan; Tao Huang; Daping Zhang; Yujie Wei; Lifeng Li; Wu Yao; Liuxin Cui; Xiaoshan Zhou; Yongli Yang; Wei Wang; Jie Zhao

doi:10.1016/j.ecoenv.2022.114489

Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers

Ecotoxicol Environ Saf. 2023 Jan 15:250:114489. doi: 10.1016/j.ecoenv.2022.114489. Epub 2023 Jan 3.

Authors

Xiaoran Duan¹, Tao Huang², Daping Zhang³, Yujie Wei⁴, Lifeng Li⁴, Wu Yao⁵, Liuxin Cui⁵, Xiaoshan Zhou⁵, Yongli Yang⁶, Wei Wang⁷, Jie Zhao⁸

Affiliations

¹ National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, Henan, China; Medical School, Huanghe Science and Technology University, Zhengzhou, Henan, China; Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
² Medical School, Huanghe Science and Technology University, Zhengzhou, Henan, China.
³ Department of Cardiology, Huaihe Hospital of Henan University, Kaifeng 475000, Henan, China.
⁴ National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, Henan, China.
⁵ Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
⁶ Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
⁷ Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China. Electronic address: ww375@zzu.edu.cn.
⁸ National Engineering Laboratory for Internet Medical Systems and Applications, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, Henan, China. Electronic address: zhaojie@zzu.edu.cn.

PMID: 36603485
DOI: 10.1016/j.ecoenv.2022.114489

Abstract

Coke oven emissions (COEs) contain many carcinogenic polycyclic aromatic hydrocarbons (PAHs). Telomere damage is an early biological marker reflecting long-term COEs-exposure. Whereas, whether the genetic variations of telomere-regulated gene TNKS have an effect on the COEs-induced telomere damage is unknown. So we detected the environmental exposure levels, relative telomere length (RTL), and TNKS genetic polymorphisms among 544 COEs-exposure workers and 238 healthy participants. We found that the RTL of the wild homozygous GG genotype in rs1055328 locus was statistically shorter compared with the CG+CC genotype for the healthy participants using covariance analysis(P = 0.008). In the Generalized linear model (GLM) analysis, TNKS rs1055328 GG could accelerate telomere shortening (P = 0.011); and the interaction between TNKS rs1055328 GG and COEs-exposure had an effect on RTL (P = 0.002). In conclusion, this study was the first to discover the role of TNKS rs1055328 locus in COEs-induced telomere damage, and proved that chromosomal damage was a combined consequence of environmental and genetic factors.

Keywords: Coke Oven Emissions; TNKS gene; Telomere Damage.

MeSH terms

Coke* / adverse effects
DNA Damage
Humans
Occupational Exposure* / adverse effects
Occupational Exposure* / analysis
Polycyclic Aromatic Hydrocarbons* / analysis
Polycyclic Aromatic Hydrocarbons* / toxicity
Polymorphism, Genetic
Tankyrases* / genetics
Telomere / genetics

Substances

Coke
Polycyclic Aromatic Hydrocarbons
Tankyrases
TNKS protein, human