We report a facile room temperature telescoping synthesis of a nanocurcumin complex with 17.5-fold permeation enhancement as determined by comparative in vitro permeation study with raw curcumin. The permeation results were further validated with in silico drug absorption prediction using ADMET predictors.
Keywords: DFT simulation; PEG conjugation; nanocurcumin; permeation potential; telescoping synthesis.
© 2023 The Authors. Published by Wiley-VCH GmbH.