A Xanthan-Gum-Stabilized PEG-Conjugated Nanocurcumin Complex: Telescoping Synthesis for Enhanced Permeation Potential

ChemistryOpen. 2023 Jan;12(1):e202200200. doi: 10.1002/open.202200200.

Abstract

We report a facile room temperature telescoping synthesis of a nanocurcumin complex with 17.5-fold permeation enhancement as determined by comparative in vitro permeation study with raw curcumin. The permeation results were further validated with in silico drug absorption prediction using ADMET predictors.

Keywords: DFT simulation; PEG conjugation; nanocurcumin; permeation potential; telescoping synthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Curcumin*
  • Nanoparticles*
  • Polysaccharides, Bacterial

Substances

  • xanthan gum
  • Curcumin
  • Polysaccharides, Bacterial