Illuminating lactate in cells, mice, and patient samples

Zefan Li; Hui-Wang Ai

doi:10.1016/j.cmet.2022.12.007

Illuminating lactate in cells, mice, and patient samples

Cell Metab. 2023 Jan 3;35(1):5-7. doi: 10.1016/j.cmet.2022.12.007.

Authors

Zefan Li¹, Hui-Wang Ai²

Affiliations

¹ Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
² Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; The UVA Comprehensive Cancer Center, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: huiwang.ai@virginia.edu.

Abstract

Lactate has emerged as a central metabolic fuel and an important signaling molecule. In this issue of Cell Metabolism, Li et al. develop a high-quality lactate sensor, allowing them to monitor lactate levels in cells, subcellular organelles, live mice, and human body fluids.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Humans
Lactic Acid* / metabolism
Mice
Signal Transduction*

Substances

Lactic Acid

Abstract

Publication types

MeSH terms

Substances

Grants and funding