Tuberculous spondylitis following intravesical Bacillus Calmette-Guérin therapy for bladder cancer surgically treated through the anterior approach

BMJ Case Rep. 2022 Dec 9;15(12):e251075. doi: 10.1136/bcr-2022-251075.

Abstract

Intravesical BCG therapy is commonly used to treat superficial bladder cancer. Although various complications associated with this therapy have been reported, tuberculous spondylitis is uncommon. Here, we report a rare case of tuberculous spondylitis that occurred after intravesical BCG therapy for bladder cancer. A man in his 80s received BCG immunotherapy for bladder cancer and developed low back pain after treatment. Remarkably, he presented with neurological symptoms. Spondylitis was suspected on imaging. CT-guided biopsy was performed to confirm the diagnosis. Consequently, Mycobacterium bovis was identified as the causative pathogen by multiplex PCR. Multidrug therapy, administered for several months, was ineffective. Therefore, surgery was performed through an anterior approach. The symptoms, including low back pain, improved and postoperative C reactive protein tests were within the normal range. Tuberculous spondylitis following BCG therapy should be considered in cases with a history of bladder cancer treatment.

Keywords: Bone and joint infections; Neurosurgery; Spinal cord; Urology.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravesical
  • Aged, 80 and over
  • BCG Vaccine* / adverse effects
  • BCG Vaccine* / therapeutic use
  • Drug Therapy, Combination
  • Humans
  • Leprostatic Agents / therapeutic use
  • Low Back Pain* / diagnostic imaging
  • Low Back Pain* / etiology
  • Male
  • Mycobacterium bovis*
  • Spondylitis* / diagnosis
  • Spondylitis* / microbiology
  • Tuberculosis, Spinal* / diagnosis
  • Tuberculosis, Spinal* / microbiology
  • Urinary Bladder Neoplasms* / complications
  • Urinary Bladder Neoplasms* / drug therapy
  • Urinary Bladder Neoplasms* / surgery

Substances

  • BCG Vaccine
  • Leprostatic Agents