Nanobubble technologies: Applications in therapy from molecular to cellular level

Helena H W B Hansen; Haotian Cha; Lingxi Ouyang; Jun Zhang; Bo Jin; Helen Stratton; Nam-Trung Nguyen; Hongjie An

doi:10.1016/j.biotechadv.2022.108091

Nanobubble technologies: Applications in therapy from molecular to cellular level

Biotechnol Adv. 2023 Mar-Apr:63:108091. doi: 10.1016/j.biotechadv.2022.108091. Epub 2022 Dec 30.

Authors

Helena H W B Hansen¹, Haotian Cha¹, Lingxi Ouyang¹, Jun Zhang¹, Bo Jin², Helen Stratton³, Nam-Trung Nguyen⁴, Hongjie An⁵

Affiliations

¹ Queensland Micro and Nanotechnology Centre, Griffith University, 170 Kessels Road, Nathan, QLD 4111, Australia.
² School of Chemical Engineering and Advanced Materials, The University of Adelaide, Adelaide, SA 5005, Australia.
³ School of Environment and Science, Griffith University, Nathan, QLD 4111, Australia.
⁴ Queensland Micro and Nanotechnology Centre, Griffith University, 170 Kessels Road, Nathan, QLD 4111, Australia. Electronic address: nam-trung.nguyen@griffith.edu.au.
⁵ Queensland Micro and Nanotechnology Centre, Griffith University, 170 Kessels Road, Nathan, QLD 4111, Australia. Electronic address: hongjie.an@griffith.edu.au.

PMID: 36592661
DOI: 10.1016/j.biotechadv.2022.108091

Abstract

Nanobubbles are gaseous entities suspended in bulk liquids that have widespread beneficial usage in many industries. Nanobubbles are already proving to be versatile in furthering the effectiveness of disease treatment on cellular and molecular levels. They are functionalized with biocompatible and stealth surfaces to aid in the delivery of drugs. At the same time, nanobubbles serve as imaging agents due to the echogenic properties of the gas core, which can also be utilized for controlled and targeted delivery. This review provides an overview of the biomedical applications of nanobubbles, covering their preparation and characterization methods, discussing where the research is currently focused, and how they will help shape the future of biomedicine.

Keywords: Drug Delivery; Nanobubbles; Pharmacodynamics; Pharmacokinetics; Therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Drug Delivery Systems* / methods
Gases*
Pharmaceutical Preparations

Substances

Pharmaceutical Preparations
Gases