Ligand-Promoted [Pd]-Catalyzed α-Alkylation of Ketones through a Borrowing-Hydrogen Approach

Seetharaman Manojveer; Nitish K Garg; Zarif Gul; Ayesha Kanwal; Yogesh Goriya; Magnus T Johnson

doi:10.1002/open.202200245

Ligand-Promoted [Pd]-Catalyzed α-Alkylation of Ketones through a Borrowing-Hydrogen Approach

ChemistryOpen. 2023 Jan;12(1):e202200245. doi: 10.1002/open.202200245.

Authors

Seetharaman Manojveer¹, Nitish K Garg¹, Zarif Gul¹, Ayesha Kanwal¹, Yogesh Goriya¹, Magnus T Johnson^{1

2}

Affiliations

¹ Centre for Analysis and Synthesis, Department of Chemistry, Lund University, P. O. Box 124, 221 00, Lund, Sweden.
² Perstorp AB, Perstorp Industrial Park, 284 80, Perstorp, Sweden.

Abstract

A new class of palladium complexes bearing bidentate 2-hydroxypyridine based ligands have been prepared and fully characterized. The applications of these new complexes towards ketone alkylation reactions with alcohols through a metal-ligand cooperative borrowing-hydrogen (BH) process were demonstrated.

Keywords: 2-hydroxypyridine; MLC; borrowing-hydrogen; catalysis; α-alkylation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkylation
Catalysis
Hydrogen*
Ketones*
Ligands

Substances

Ligands
Ketones
Hydrogen