Protein Kinases as Potential Targets Contribute to the Development of Agrochemicals

J Agric Food Chem. 2023 Jan 11;71(1):52-64. doi: 10.1021/acs.jafc.2c06222. Epub 2023 Jan 2.

Abstract

Using agrochemicals against pest insects, fungi, and weeds plays a major part in maintaining and improving crop yields, which helps to solve the issue of food security. Due to the limited targets and resistance of agrochemicals, protein kinases are regarded as attractive potential targets to develop new agrochemicals. Recently, a lot of investigations have shown the extension of agrochemicals by targeting protein kinases, implying an increasing concern for this kind of method. However, few people have summarized and discussed the targetability of protein kinases contributing to the development of agrochemicals. In this work, we introduce the research on protein kinases as potential targets used in crop protection and discuss the prospects of protein kinases in the field of agrochemical development. This study may not only provide guidance for the contribution of protein kinases to the development of agrochemicals but also help nonprofessionals such as students learn and understand the role of protein kinases quickly.

Keywords: agrochemicals discovery; antifungals; plant immunity; protein kinases; stress tolerance; targetability.

Publication types

  • Review

MeSH terms

  • Agrochemicals* / pharmacology
  • Animals
  • Crop Protection
  • Humans
  • Insecta*
  • Plant Weeds

Substances

  • Agrochemicals