The roles of long non‑coding RNAs in renal cell carcinoma (Review)

Zhengming Su; Jian Ao; Fengjin Zhao; Guibin Xu; Huihua Chen; Chen Gao

doi:10.3892/mco.2022.2600

The roles of long non‑coding RNAs in renal cell carcinoma (Review)

Mol Clin Oncol. 2022 Nov 28;18(1):4. doi: 10.3892/mco.2022.2600. eCollection 2023 Jan.

Authors

Zhengming Su¹, Jian Ao², Fengjin Zhao¹, Guibin Xu¹, Huihua Chen³, Chen Gao⁴

Affiliations

¹ Department of Urology, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, P.R. China.
² Department of General Surgery, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, P.R. China.
³ Department of Education Management Section, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, P.R. China.
⁴ Department of Operating Room, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.

Abstract

Long non-coding RNAs (lncRNAs) are involved in the gene expression regulation and usually play important roles in various human cancers, including the renal cell carcinoma (RCC). Dysregulation of certain lncRNAs are associated with the prognosis of patients with RCC. In the present review, several recently studied lncRNAs were discussed and their critical roles in proliferation, migration, invasion, apoptosis and drug resistance of renal cancer cells were revealed. The research on lncRNAs further increases our understanding on the development and progression of RCC. It is suggested that lncRNAs can be used as biomarkers or therapeutic targets for diagnosis or treatment of renal cancer.

Keywords: long non-coding RNAs; renal cell carcinoma.

Publication types

Review

Grants and funding

Funding: The present study was supported by the Medical Research Foundation of Guangdong Province of China (grant no. A2021351), the Guangzhou Science and Technology Project of Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine (grant no. 20222A010053), the Key Laboratory of Guangdong Higher Education Institutes (grant no. 2021KSYS009), the University-level Key Clinical Specialty Project of Guangzhou Medical University (grant no. 2020-5) and the Guangzhou Core Medical Disciplines Project (grant no. 2021-2023).