De Novo Autoimmune Hepatitis after COVID-19 Infection in an Unvaccinated Patient

Francisco A Durazo; Kelly Kristbaum; James Miller; Kia Saeian; Motaz Selim; Johnny C Hong

doi:10.1155/2022/8409269

De Novo Autoimmune Hepatitis after COVID-19 Infection in an Unvaccinated Patient

Case Reports Hepatol. 2022 Dec 22:2022:8409269. doi: 10.1155/2022/8409269. eCollection 2022.

Authors

Francisco A Durazo^{1

2}, Kelly Kristbaum¹, James Miller³, Kia Saeian², Motaz Selim¹, Johnny C Hong⁴

Affiliations

¹ Division of Transplant Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
² Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
³ Department of Pathology and Laboratory Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
⁴ Division of Transplantation, Pennsylvania State University, College of Medicine Penn State Health Milton S. Hershey Medical Center Hershey, Pennsylvania, USA.

Abstract

Liver test abnormalities have been described during severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection causing coronavirus disease 2019. Most of them consist of elevation of the aminotransferases that resolve once the infection subsides. There are several reports of autoimmune hepatitis developing after vaccination against COVID-19 and one case of autoimmune hepatitis following COVID-19 infection. We present a patient that was not vaccinated against COVID-19 and developed resistant de novo autoimmune hepatitis following COVID-19 infection requiring aggressive immunosuppression.

Publication types

Case Reports