Peptide hydrogel based sponge patch for wound infection treatment

Lanxin Li; Yuan Zhou; Peizhe Li; Qi Xu; Kaiyan Li; Hai Hu; Wei Bing; Zhijun Zhang

doi:10.3389/fbioe.2022.1066306

Peptide hydrogel based sponge patch for wound infection treatment

Front Bioeng Biotechnol. 2022 Dec 15:10:1066306. doi: 10.3389/fbioe.2022.1066306. eCollection 2022.

Authors

Lanxin Li¹, Yuan Zhou^{2

3}, Peizhe Li⁴, Qi Xu⁵, Kaiyan Li⁵, Hai Hu⁵, Wei Bing¹, Zhijun Zhang⁴

Affiliations

¹ School of Chemistry and Life Science, Changchun University of Technology, Changchun, China.
² Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
³ College of Pharmacy, Hubei University of Traditional Chinese Medicine, Wuhan, China.
⁴ Key Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang Province, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, China.
⁵ Shanghai Beautyart Biotechnology Co., Ltd., Shanghai, China.

Abstract

Dressing with the function of anti-wound infection and promoting skin repair plays an important role in medicine, beauty industry, etc. In terms of anti-wound infection, traditional dressings, such as gauze, have problems such as excessive bleeding in the process of contact or removal, and slow wound healing due to poor biological compatibility. The development of new functional and biocompatible dressings has essential application value in biomedical fields. In this study, a new type of dressing based on polypeptide functional sponge patch was constructed. The porous sponge patch is made of antimicrobial peptide and medical agarose through gel and freeze-drying technology. In vitro antibacterial experiments and small animal skin wound infection model experiments show that the porous sponge has excellent antibacterial and anti-skin infection activities, as well as the function of promoting wound healing.

Keywords: bacterial infection; medical dressings; peptide hydrogel; sponge patch; wound healing.