Applying multi-omics techniques to the discovery of biomarkers for acute aortic dissection

Xinyu Hao; Shuai Cheng; Bo Jiang; Shijie Xin

doi:10.3389/fcvm.2022.961991

Applying multi-omics techniques to the discovery of biomarkers for acute aortic dissection

Front Cardiovasc Med. 2022 Dec 15:9:961991. doi: 10.3389/fcvm.2022.961991. eCollection 2022.

Authors

Xinyu Hao^{1

2}, Shuai Cheng^{1

2}, Bo Jiang^{1

2}, Shijie Xin^{1

2}

Affiliations

¹ Department of Vascular Surgery, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, China.
² Key Laboratory of Pathogenesis, Prevention and Therapeutics of Aortic Aneurysm, Shenyang, Liaoning, China.

Abstract

Acute aortic dissection (AAD) is a cardiovascular disease that manifests suddenly and fatally. Due to the lack of specific early symptoms, many patients with AAD are often overlooked or misdiagnosed, which is undoubtedly catastrophic for patients. The particular pathogenic mechanism of AAD is yet unknown, which makes clinical pharmacological therapy extremely difficult. Therefore, it is necessary and crucial to find and employ unique biomarkers for Acute aortic dissection (AAD) as soon as possible in clinical practice and research. This will aid in the early detection of AAD and give clear guidelines for the creation of focused treatment agents. This goal has been made attainable over the past 20 years by the quick advancement of omics technologies and the development of high-throughput tissue specimen biomarker screening. The primary histology data support and add to one another to create a more thorough and three-dimensional picture of the disease. Based on the introduction of the main histology technologies, in this review, we summarize the current situation and most recent developments in the application of multi-omics technologies to AAD biomarker discovery and emphasize the significance of concentrating on integration concepts for integrating multi-omics data. In this context, we seek to offer fresh concepts and recommendations for fundamental investigation, perspective innovation, and therapeutic development in AAD.

Keywords: acute aortic dissection; biomarkers; diagnostics; high-throughput sequencing technology; integrated strategies; mass spectrometry technology; multi-omics.

Publication types

Review