Association between serum uric acid levels and the prevalence of heart failure due to acute coronary syndrome in Chinese hospitalized patients: A cross-sectional study

Guotong Sun; Yu Liu; Di Rong; Xiuwen Liang

doi:10.1016/j.numecd.2022.11.006

Association between serum uric acid levels and the prevalence of heart failure due to acute coronary syndrome in Chinese hospitalized patients: A cross-sectional study

Nutr Metab Cardiovasc Dis. 2023 Feb;33(2):308-314. doi: 10.1016/j.numecd.2022.11.006. Epub 2022 Nov 6.

Authors

Guotong Sun¹, Yu Liu², Di Rong³, Xiuwen Liang⁴

Affiliations

¹ Suzhou Medical College of Soochow University, Soochow University, Suzhou, 215000, Jiangsu, China; Department of Cardiology, Hulunbuir People's Hospital, Hulunbuir, 021000, Inner Mongolia, China; Department of Cardiology, Shouguang Hospital of T.C.M, Weifang, 262700, Shandong, China.
² Department of Cardiology, Hulunbuir People's Hospital, Hulunbuir, 021000, Inner Mongolia, China; Medical College, Inner Mongolia Minzu University, Tongliao, 028000, Inner Mongolia, China.
³ Suzhou Medical College of Soochow University, Soochow University, Suzhou, 215000, Jiangsu, China; Department of Geriatric, Hulunbuir People's Hospital, Hulunbuir, 021000, Inner Mongolia, China.
⁴ Suzhou Medical College of Soochow University, Soochow University, Suzhou, 215000, Jiangsu, China; Medical College, Inner Mongolia Minzu University, Tongliao, 028000, Inner Mongolia, China; Department of Cardiology, Hulunbeir China Mongolia Hospital, Hulunbuir, 021000, Inner Mongolia, China. Electronic address: 20214155004@stu.suda.edu.cn.

PMID: 36586774
DOI: 10.1016/j.numecd.2022.11.006

Abstract

Background and aims: Serum uric acid (SUA) may play a role in heart failure (HF). Our study was to find relationships between SUA and the prevalence of HF due to acute coronary syndrome (ACS), and the ethnic-specific relationship between them in an inpatient population.

Methods and results: We analyzed 1075 Chinese ACS patients. SUA levels were cut to four groups as Q1 to Q4, according to quartiles. Binary logistic regression models were used to assess associations of SUA with HF due to ACS. Subgroup analysis was performed to find ethnic-specific association between SUA and HF due to ACS. We also performed univariate and multivariate logistic regression analyses taking into account an Italian's cut-off for SUA for HF prognosis stratification. After adjustment for all potential confounders, compared to the lowest quartile, quartiles 2, 3 and 4 had a prevalence OR of 0.69 (0.44-1.08), 1.06 (0.67-1.67) and 2.19 (1.35-3.56), respectively, for the HF due to ACS (p for trend <0.001). Subgroup analyses didn't reveal an ethnic-specific differences between SUA and HF due to ACS. In Han, the highest SUA level was significantly associated with the risk of HF due to ACS. OR with 95%CI for Q4 was 1.85 (1.02-3.37), Q1 as a reference. For Mongolians, the OR with 95%CI for Q4 was 6.82 (1.90-24.50), Q1 as a reference.

Conclusion: We found positive associations between SUA and the prevalence of HF due to ACS among Chinese patients. No differences exist regarding ethnicity.

Keywords: A cross-sectional study; Acute coronary syndrome; Heart failure; Logistic regression analysis; Serum uric acid.

MeSH terms

Acute Coronary Syndrome* / diagnosis
Acute Coronary Syndrome* / epidemiology
Cross-Sectional Studies
East Asian People
Heart Failure* / diagnosis
Heart Failure* / epidemiology
Humans
Prevalence
Risk Factors
Uric Acid

Substances

Uric Acid