Polysaccharide-based nanocarriers for efficient transvascular drug delivery

Min Zhang; He Ma; Xijie Wang; Bing Yu; Hailin Cong; Youqing Shen

doi:10.1016/j.jconrel.2022.12.051

Polysaccharide-based nanocarriers for efficient transvascular drug delivery

J Control Release. 2023 Feb:354:167-187. doi: 10.1016/j.jconrel.2022.12.051. Epub 2023 Jan 9.

Authors

Min Zhang¹, He Ma¹, Xijie Wang¹, Bing Yu², Hailin Cong³, Youqing Shen⁴

Affiliations

¹ Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China.
² Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China. Electronic address: yubing198@qdu.edu.cn.
³ Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China; School of Materials Science and Engineering, Shandong University of Technology, Zibo 255000, China. Electronic address: conghailin@sdut.edu.cn.
⁴ Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China; Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

PMID: 36581260
DOI: 10.1016/j.jconrel.2022.12.051

Abstract

Polysaccharide-based nanocarriers (PBNs) are the focus of extensive investigation because of their biocompatibility, low cost, wide availability, and chemical versatility, which allow a wide range of anticancer agents to be loaded within the nanocarriers. Similar to other nanocarriers, most PBNs are designed to extravasate out of tumor vessels, depending on the enhanced permeability and retention (EPR) effect. However, the EPR effect is compromised in some tumors due to the heterogeneity of tumor structures. Transvascular transport efficacy is decreased by complex blood vessels and condensed tumor stroma. The limited extravasation impedes efficient drug delivery into tumor parenchyma, and thus affects the subsequent tumor accumulation, which hinders the therapeutic effect of PBNs. Therefore, overcoming the biological barriers that restrict extravasation from tumor vessels is of great importance in PBN design. Many strategies have been developed to enhance the EPR effect that involve nanocarrier property regulation and tumor structure remodeling. Moreover, some researchers have proposed active transcytosis pathways that are complementary to the paracellular EPR effect to increase the transvascular extravasation efficiency of PBNs. In this review, we summarize the recent advances in the design of PBNs with enhanced transvascular transport to enable optimization of PBNs in the extravasation of the drug delivery process. We also discuss the obstacles and challenges that need to be addressed to clarify the transendothemial mechanism of PBNs and the potential interactions between extravasation and other drug delivery steps.

Keywords: Increased delivery efficacy; Intratumoral drug transportation; Polysaccharide-based nanocarriers; Transvascular extravasation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents* / therapeutic use
Drug Delivery Systems
Humans
Nanoparticles* / chemistry
Neoplasms* / drug therapy
Polysaccharides

Substances

Antineoplastic Agents
Polysaccharides