A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics

Nephron. 2023;147(7):434-440. doi: 10.1159/000528259. Epub 2022 Dec 29.

Abstract

Background: Alterations of renal hemodynamics play an essential role in renal homeostasis and kidney diseases. Recent data indicated that semaphorin 3C (SEMA3C), a secreted glycoprotein involved in vessel development, can modulate renal vascular permeability in acute kidney injury, but whether and how it might impact systemic and renal hemodynamics is unknown.

Objectives: The objective of the study was to explore the effect of SEMA3C on systemic and renal hemodynamics.

Methods: SEMA3C recombinant protein was administered intravenously in two-month-old wild-type mice, and the variations of mean arterial pressure, heart rate, renal blood flow, and renal vascular resistance were measured and analyzed.

Results: Acute administration of SEMA3C induced (i) systemic hemodynamic changes, including mean arterial pressure decrease and heart rate augmentation; (ii) renal hemodynamic changes, including reduced vascular resistance and elevated renal blood flow. Continuous perfusion of SEMA3C had no significant effect on systemic or renal hemodynamics.

Conclusion: SEMA3C is a potent vasodilator affecting both systemic and renal hemodynamics in mice.

Keywords: Mean arterial pressure; Renal blood flow; Semaphorin 3C.

Publication types

  • News

MeSH terms

  • Animals
  • Heart Rate
  • Hemodynamics* / physiology
  • Kidney / metabolism
  • Mice
  • Renal Circulation / physiology
  • Semaphorins* / metabolism
  • Semaphorins* / pharmacology
  • Vascular Resistance

Substances

  • Semaphorins

Grants and funding

This study was supported by the INSERM and Sorbonne University, a National Academy of Medicine fellowships to ACai, an ANR grant [19-CE14-0011-01] to C.C., a Marie Curie Personal Fellowship [704450, Horizon2020] to A.C., and a BAYER Grants4Targets [ID 2017-08-2159] to A.C.