Circular RNAs (circRNAs), a novel type of covalently closed non-coding RNAs, are widely expressed in eukaryotes and viruses. Accumulating evidence has shown that circRNAs play key roles in the pathophysiological changes process of human diseases and can affect cancer development and progression through regulating target genes expression, linear RNA transcription and protein generation. Recent studies had found that circRNA-UBAP2 (ubiquitin binding associated protein 2) was aberrantly expressed in various human tumors and could affect tumor cells proliferation, migration, invasion, cell cycle, anti-apoptosis, radioresistance, chemoresistance and other malignant biological behavioral progress. Mechanistic studies further revealed that circUBAP2 could affect the occurrence and development of human tumors through multiple different molecular regulatory pathways in vivo and in vitro. In addition, the abnormal expression of circUBAP2 was significantly correlated with the clinicopathological characteristics of malignant tumors and had potential value as biomarkers for the diagnosis and prognosis evaluation of cancer patients, which deserved further study. This review had summarized and discussed the oncogenic roles and clinical performances of circUBAP2 in various human malignancies with a focus on biological functions and molecular mechanisms, which could help to elevate the understanding to the roles of circRNAs and continue subsequent studies on circUBAP2.
Keywords: Biological function; Cancer; CircUBAP2; Circular RNA; Molecular mechanism.
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