Editorial: Pharmacokinetic differences of drugs and their regulatory mechanisms under dual status including normal and diseased organism

Zipeng Gong; Jie Zhou; Ling Ye; Guo Ma; Yanfang Xian; Kaustubh Kulkarni

doi:10.3389/fphar.2022.1063434

Editorial: Pharmacokinetic differences of drugs and their regulatory mechanisms under dual status including normal and diseased organism

Front Pharmacol. 2022 Dec 12:13:1063434. doi: 10.3389/fphar.2022.1063434. eCollection 2022.

Authors

Zipeng Gong^{1

2

3}, Jie Zhou¹, Ling Ye⁴, Guo Ma⁵, Yanfang Xian⁶, Kaustubh Kulkarni⁷

Affiliations

¹ State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, School of Pharmacy, Guizhou Medical University, Guiyang, China.
² Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, China.
³ Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guiyang, China.
⁴ NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
⁵ School of Pharmacy, Fudan University, Shanghai, China.
⁶ School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, Hong Kong SAR, China.
⁷ Boundless Bio Inc., San Diego, CA, United States.

No abstract available

Keywords: drug metabolizing enzymes; dual status; nuclear receptors; pharmacokinetic differences; pharmacokinetic-pharmacodynamic model; transporters.

Publication types

Editorial