Volumetric parameters of the primary tumor and whole-body tumor burden derived from baseline 18F-FDG PET/CT can predict overall survival in non-small cell lung cancer patients: initial results from a single institution

Hemat A Mahmoud; Walaa Oteify; Hussein Elkhayat; Ahmed M Zaher; Taha Zaki Mohran; Nesreen Mekkawy

doi:10.1186/s41824-022-00158-x

Volumetric parameters of the primary tumor and whole-body tumor burden derived from baseline ¹⁸F-FDG PET/CT can predict overall survival in non-small cell lung cancer patients: initial results from a single institution

Eur J Hybrid Imaging. 2022 Dec 28;6(1):37. doi: 10.1186/s41824-022-00158-x.

Authors

Hemat A Mahmoud¹, Walaa Oteify², Hussein Elkhayat³, Ahmed M Zaher⁴, Taha Zaki Mohran², Nesreen Mekkawy²

Affiliations

¹ Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Assiut University, Asyût, Egypt. hemat.ahmad2012@yahoo.com.
² Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Assiut University, Asyût, Egypt.
³ Cardiothoracic Surgery Department, Faculty of Medicine, Assiut University, Asyût, Egypt.
⁴ Nuclear Medicine Department, National Cancer Institute, Cairo University, Cairo, Egypt.

Abstract

Background: Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) are volumetric parameters derived from ¹⁸F-FDG PET/CT, suggested to have a prognostic value in cancer patients. Our study aimed to test whether these volumetric parameters of the primary tumor and whole-body tumor burden (WBTB) can predict overall survival (OS) in non-small cell lung cancer (NSCLC) patients.

Materials and methods: Thirty biopsy-proven NSCLC patients who had not begun anti-tumor therapy were included in this prospective study. A baseline ¹⁸F-FDG PET/CT study was acquired. Scans were interpreted visually and semi-quantitatively by drawing a 3D volume of interest (VOI) over the primary tumor and all positive lesions to calculate metabolic, volumetric parameters, and WBTB. The PET parameters were used to stratify patients into high- and low-risk categories. The overall survival was estimated from the date of scanning until the date of death or last follow-up.

Results: At a median follow-up of 22.73 months, the mean OS was shorter among patients with higher tu MTV and tu TLG and high WBTB. High WB TLG was independently associated with the risk of death (p < 0.025). Other parameters, e.g., SUV_max, SUV_peak, and SUV_mean, were not predictive of outcomes in these patients.

Conclusion: In patients with NSCLC, tu MTV, tu TLG, and WBTB determined on initial staging ¹⁸F-FDG PET/CT seems to be a strong, independent imaging biomarker to predict OS, superior to the clinical assessment of the primary tumor. The WB TLG was found to be the best predictor of OS.

Keywords: 18F-FDG PET/CT; Non-small cell lung cancer; Overall survival; Whole-body tumor burden.