Recent advances on human mpox

Aliya Orassay; Alan Berdigaliyev; Darya Sadvokassova; Ansal Diassova; Amr Amin; Wenwen Cao; Yingqiu Xie

doi:10.1016/j.nmni.2022.101066

Recent advances on human mpox

New Microbes New Infect. 2023 Jan:51:101066. doi: 10.1016/j.nmni.2022.101066. Epub 2022 Dec 16.

Authors

Aliya Orassay¹, Alan Berdigaliyev¹, Darya Sadvokassova¹, Ansal Diassova¹, Amr Amin², Wenwen Cao³, Yingqiu Xie¹

Affiliations

¹ Department of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.
² Biology Department, UAE University, Al Ain, 15551, United Arab Emirates.
³ Respiratory Department, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.

Abstract

Mpox has been a concern of public health and travel caution. Using databases of WHO, CDC, google scholar, and PubMed, we searched recent literatures and reviewed the history, genomic mutation/evolution, host cell response pathways, regulation policy, vaccine and therapy development. Recent studies showed that current mpox has many genomic mutations related to regulation by APOBEC3. Current mpox has also been suggested to be associated with sexual transmission. Vaccination should be applied and anti-mpox drug should be urgently developed. More investigations are needed to ensure outbreak prevention.

Keywords: Epidemiology; Global health; Infection; Monkeypox; Mpox; Outbreak; Sexual transmission.

Publication types

Review