To investigate the role of rutin on bisphenol-A induced female infertility in rats

Abstract

Aim: The aim of this study is to see how rutin affects female infertility in rats after exposure to bisphenol-A (BA).

Background: Now a day, infertility is a major issue in the health care system. Currently, various chemicals and toxins are exposed to our biological system. Moreover, globally the improvement in reproductive health is alarming in developing and developed countries. The complete understanding and full therapeutic spectrum of natural medicines like citrus fruit-derived phytoconstituent i.e., rutin is not explored yet. However, rutin is contributed to the improvement of vascular health and smooth muscle tissue functions.

Objective: The proposed research work is designed to explore the role of rutin on bisphenol-A (BA) induced female infertility in rats.

Materials/methods: BA is a potent endocrine disruptor and it causes female infertility in the rat. The inducer of oocyte maturation with nitric oxide donor i.e., sodium nitroprusside (SNP) was used for female infertility in the rat. The test compound rutin was administered with variable doses for 60 minutes per day for 21 days for this study.

Results: The female infertility of rats was assessed by male-female interaction behaviours, and anxiety behaviours were tested on 0, 7, 14, and 21st days. The biomarkers levels i.e., estradiol-17b (E2), follicle-stimulating hormone (FSH) and antimullerian tubulin hormone (AMH), reduced glutathione (GSH), and lipid peroxidation (MDA) levels were estimated at the end of the experimental protocol.

Conclusion: The treatment of rutin is ameliorated the BA-associated female reproductive behaviours and biomarkers level. Hence, it may be useful to improve female reproductive health due to its potential multi-targeted actions like hormonal regulation, anti-oxidant, and anti-peroxidative actions.

Keywords: Antimullerian tubulin hormone; endocrine disruptors; nitric oxide donor; oocyte maturation; reduced glutathione..