Towards a collective biology of the gene

J Theor Biol. 1987 May 21;126(2):127-36. doi: 10.1016/s0022-5193(87)80224-2.

Abstract

Two features of heterochromatin: heteropycnosis (high values of chromatin condensation), and repressed genetic expression, force upon us the use of cooperative variables, rather than molecular ones. In particular a "repressor" hypothesis is formulated, in which a useful parameter is clearly identified. This enables us to discuss the synchronized repression of a large number, n, of genes (as in the case of the Barr body, in which n is larger than 100). The hypothesis is documented with phenomena known to occur in active chromatin. Possible tests are suggested.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes* / metabolism
  • Female
  • Gene Expression Regulation
  • Genes*
  • Humans
  • Molecular Biology*
  • Protein Biosynthesis
  • Quantum Theory
  • Repressor Proteins / metabolism
  • Transcription, Genetic

Substances

  • Repressor Proteins