Reversible Calcineurin Inhibitor-associated Sensorimotor Polyneuropathy in a Lung Transplant Recipient: A Case Report

T Antychin; J A Zarowski; V Verplancke; J M H Hendriks; S K Yogeswaran; P Lauwers; K Lamote; J M Kwakkel-van Erp

Reversible Calcineurin Inhibitor-associated Sensorimotor Polyneuropathy in a Lung Transplant Recipient: A Case Report

Int J Organ Transplant Med. 2021;12(4):60-64.

Authors

T Antychin^{1

2}, J A Zarowski^{1

2}, V Verplancke^{1

2

3}, J M H Hendriks⁴, S K Yogeswaran⁴, P Lauwers⁴, K Lamote^{2

3

5}, J M Kwakkel-van Erp^{1

2

3}

Affiliations

¹ Department of Pulmonology, Antwerp University Hospital, Edegem, Belgium.
² Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Wilrijk, Belgium.
³ Infla-Med Centre of Excellence, University of Antwerp, Wilrijk, Belgium.
⁴ Department of Thoracic and Vascular Surgery, Antwerp University Hospital, Edegem, Belgium.
⁵ Department of Internal Medicine, Ghent University, Ghent, Belgium.

PMID: 36570353
PMCID: PMC9758996

Abstract

Calcineurin inhibitors (CNIs) are regarded as a corner stone in immunosuppressive therapy after solid organ transplantation. However, neurotoxicity is a common side effect of CNIs, resulting in a wide range of neurological symptoms such as headache, tremor and seizures. In this case report, we describe a patient who developed severe motor and sensory neuron dysfunction related to CNIs after bilateral lung transplantation, which resolved after halting CNI and switching to a mammalian Target of Rapamycin-inhibitor.

Keywords: Calcineurin inhibitors; Lung transplantation; Reversible neuropathy; mTOR-inhibitor.

Publication types

Case Reports