Antiviral activity of Lavandula angustifolia L. and Salvia officinalis L. essential oils against avian influenza H5N1 virus

Doha H Abou Baker; Ryszard Amarowicz; Ahmed Kandeil; Mohamed A Ali; Eman A Ibrahim

doi:10.1016/j.jafr.2021.100135

Antiviral activity of Lavandula angustifolia L. and Salvia officinalis L. essential oils against avian influenza H5N1 virus

J Agric Food Res. 2021 Jun:4:100135. doi: 10.1016/j.jafr.2021.100135. Epub 2021 Mar 10.

Authors

Doha H Abou Baker¹, Ryszard Amarowicz², Ahmed Kandeil³, Mohamed A Ali³, Eman A Ibrahim⁴

Affiliations

¹ Department of Medicinal and Aromatic Plants, National Research Centre (NRC), 33 El Bohouth St. (former El Tahrirst.), Dokki, Giza, Egypt.
² Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-748-Olsztyn, Tuwima Street 10, Poland.
³ Center of Scientific Excellence for Influenza Viruses, Department of Water Pollution Research, Division of Environmental Research, National Research Centre (NRC), Egypt.
⁴ Department of Plant Biochemistry, National Research Centre (NRC), 33 El Bohouth St., Dokki, Giza, Egypt.

Abstract

Nowadays, viral infection is considered a major cause of mortality all over the world such as covid-19 pandemic. In this context, searching for antiviral agents are major researchers interests. In this study, essential oils (EO) of Lavandula angustifolia (lavender) and Salvia officinalis (salvia) were subjected to combat avian influenza H5N1 virus. Laboratory trials were performed to identify Lavender and salvia EOs and evaluate their antioxidant, anti-inflammatory and antiviral activity against an avian influenza H5N1 virus. EOs were prepared by the hydrodistillation of air-dried plants and analyzed by GC-MS methods. The results revealed that salvia has the highest EOs yield 1.3% than lavender 1%. The dominant constituents of lavender EO were linalyl acetate and linalool while camphor and α-thujone were the dominant compounds of salvia. Both oils exhibited antioxidant activity in DPPH and ABTS and total antioxidant capacity assays. The results suggest the use of salvia and lavender EOs as effective natural anti-inflammatory, antioxidant and antiviral agents.

Keywords: ABTS•+, 2,2-azino-bis (3-ethylbenzothiazloine-6-sulphonic acid) radical cation; Anti-inflammatory; Antioxidant; Antiviral; Avian influenza; BSA, bovine serum albumin; DPPH•, 1,1-diphenyl-2-picrylhydrazyl radical; Essential oils; FID, flame ionization detector; GC, gas chromatography; GC-MS, gas chromatography-mass spectrometry; Lavandula angustifolia; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Salvia officinalis.