4-Hydroxy-3-nitro-1,4-dihydrotriazolo[5,1- c][1,2,4]triazines: synthesis, antiviral activity, and electrochemical characteristics

R A Drokin; E A Fesenko; P N Mozharovskaia; M V Medvedeva; T S Svalova; A N Kozitsina; Ya L Esaulkova; A S Volobueva; V V Zarubaev; V L Rusinov

doi:10.1007/s11172-022-3674-0

4-Hydroxy-3-nitro-1,4-dihydrotriazolo[5,1- c][1,2,4]triazines: synthesis, antiviral activity, and electrochemical characteristics

Russ Chem Bull. 2022;71(11):2460-2466. doi: 10.1007/s11172-022-3674-0. Epub 2022 Dec 19.

Authors

Affiliations

¹ Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 ul. Mira, 620002 Yekaterinburg, Russian Federation.
² St. Petersburg Pasteur Institute, 14 ul. Mira, 197101, St. Petersburg, Russian Federation.
³ I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of Russian Academy of Sciences, 22/20 ul. S. Kovalevskoi, 620108 Yekaterinburg, Russian Federation.

Abstract

A new method for preparation of 4-hydroxy-3-nitro-1,4-dihydrotriazolo[5,1-c][1,2,4]-triazines using 1-nitro-2-morpholinoethylene and 3-diazo-1,2,4-triazoles is proposed. Antiviral activity against the Coxsackie B3 virus and electrochemical transformations of the prepared compounds are studied.

Keywords: 3-nitroazolo[5,1-c][1,2,4]triazines; Coxsackie B3 virus; antiviral activity; azolotriazines; electrochemical properties; triazines; voltammetry.